反应详情

To a solution of (R)—N—((R)-1-(1-(4-chlorophenyl)-1H-pyrazol-3-yl)ethyl)-2-methylpropane-2-sulfinamide (0.98 g, 3.01 mmol) in dioxane (10 ml) was added dropwise HCl (1.504 ml, 6.01 mmol). The reaction was stirred at room temperature for 30 minutes. LCMS indicated complete conversion to product. The reaction mixture was concentrated and DCM (20 mL) and saturated NaHCO3 solution (10 mL) was added to the residue. The mixture was stirred for 10 minutes and phases were separated. Aqueous layer was then extracted with DCM (2×10 mL), and the combined organic was dried (Na2SO4) and concentrated to give product (0.556 g). LCMS (B) m/z 222.2 (M+H)+

1. concentrationThe reaction mixture was concentrated
2. additionDCM (20 mL) and saturated NaHCO3 solution (10 mL) was added to the residue
3. stirringThe mixture was stirred for 10 minutes
4. customphases were separated
5. extractionAqueous layer was then extracted with DCM (2×10 mL)
6. dry with materialthe combined organic was dried (Na2SO4)
7. concentrationconcentrated