HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)- → 5-Chloro-6-(2,2,2-trifluoroethoxy)nicotinaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)- | HCID 61256331 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Chloro-6-(2,2,2-trifluoroethoxy)nicotinaldehyde | HCID 86730208 | 85.2% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
To a solution of (5-chloro-6-(2,2,2-trifluoroethoxyl)pyridin-3-yl)methanol (4.00 g, 16.56 mmol) in EtOAc (15 mL) was added manganese(IV) oxide (16.93 g, 166 mmol). The reaction was heated with microwave at 120° C. for 30 minutes. The mixture was then filtered through a pad of celite, and rinsed with EtOAc. The filtrated was concentrated to give crude product (3.38 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434719B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-431ab923f0694d56b75b8f4420f55947 |
| Source note | uspto-grants-2016_09 |