反应详情

温度

120 °C

To a solution of (5-chloro-6-(2,2,2-trifluoroethoxyl)pyridin-3-yl)methanol (4.00 g, 16.56 mmol) in EtOAc (15 mL) was added manganese(IV) oxide (16.93 g, 166 mmol). The reaction was heated with microwave at 120° C. for 30 minutes. The mixture was then filtered through a pad of celite, and rinsed with EtOAc. The filtrated was concentrated to give crude product (3.38 g).

1. filtrationThe mixture was then filtered through a pad of celite
2. washrinsed with EtOAc
3. concentrationThe filtrated was concentrated