反应详情

温度

100 °C

A mixture of compound 3-h (1 g, 3.0 mmol), NaOAc (0.5 g, 6.0 mmol) and hydroxyamine hydrochloride (0.31 g, 4.5 mmol) in H2O (25 mL) was stirred at 100° C. for 2 h. The precipitated was isolated by filtration to afford the product, 3-2-a, as a white solid. 1H NMR (300 MHz, DMSO-d6): δ 12.31 (s, 1H), 9.89 (s, 1H), 8.85 (s, 1H), 7.74 (s, 1H), 7.33-7.23 (m, 1H), 5.71 (s, 1H). LC-MS: (M+H)+ 349.

1. customThe precipitated was isolated by filtration
2. customto afford the product, 3-2-a