Lansoprazole → HCID 178458034, compound

HRID 574681Notes

Reaction equation

HRID 574681 reaction equation
[CH3:1][C:2]1[C:3]([O:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[CH:4][CH:5]=[N:6][C:7]=1[CH2:8][S+:9]([O-:19])[C:10]1[NH:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=2[N:18]=1.[CH:26]([NH2:29])([CH3:28])[CH3:27]>CC(OC)(C)C>[CH3:1][C:2]1[C:3]([O:20][CH2:21][C:22]([F:25])([F:23])[F:24])=[CH:4][CH:5]=[N:6][C:7]=1[CH2:8][S+:9]([O-:19])[C:10]1[NH:18][C:17]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:11]=1.[CH:26]([NH3+:29])([CH3:28])[CH3:27]

Participants

4

Reactant 2

HCID 3883LansoprazoleHCID 6363Isopropylamine

Product 1

HCID 178458034HCID 178458034, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Dexlansoprazole (2 g) in amorphous form was dissolved in MTBE (50 mL) followed by the addition of isopropyl amine (3 mL). After stirring at room temperature for 30 minutes, the resulting suspension was filtered, washed with MTBE (10 mL) and dried in vacuo at 20-25° C. to provide dexlansoprazole isopropylammonium salt (2.1 g). Molar ratio of dexlansoprazole to isopropyl amine is 1:1 by 1H NMR.

Workup

  1. filtrationthe resulting suspension was filtered
  2. washwashed with MTBE (10 mL)
  3. customdried in vacuo at 20-25° C.

Sources & evidence

ORD record
ord-19f43e129eb84ad3b6444e5ac0ef84cb
Source dataset
uspto-grants-2015_05
Patent number
US09034904B2

Reaction notes

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