3-(5-methyl-1H-imidazol-1-yl)propan-1-amine → 6-ethyl-3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3-dihydro-thieno[2,3-d]pyrimidin-4(1H)-one

HRID 574701Notes

Reaction equation

HRID 574701 reaction equation
[CH2:1]([C:3]1[S:7][C:6]([N:8]=[C:9]=[S:10])=[C:5]([C:11]([O:13]C)=O)[CH:4]=1)[CH3:2].[CH3:15][C:16]1[N:20]([CH2:21][CH2:22][CH2:23][NH2:24])[CH:19]=[N:18][CH:17]=1>>[CH2:1]([C:3]1[S:7][C:6]2[NH:8][C:9](=[S:10])[N:24]([CH2:23][CH2:22][CH2:21][N:20]3[C:16]([CH3:15])=[CH:17][N:18]=[CH:19]3)[C:11](=[O:13])[C:5]=2[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 194294833-(5-methyl-1H-imidazol-1-yl)propan-1-amineHCID 19620641Methyl 5-ethyl-2-isothiocyanatothiophene-3-carboxylate

Product 1

HCID 250998906-ethyl-3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3-dihydro-thieno[2,3-d]pyrimidin-4(1H)-one

Procedure

The compound was synthesized starting from methyl 5-ethyl-2-isothiocyanatothiophene-3-carboxylate (0.1 g, 0.44 mmol) and 3-(5-methyl-1H-imidazol-1-yl)propan-1-amine (5) (0.06 g, 0.44 mmol) as described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-ca151ab105744cb9809b6afc3f21f7da
Source dataset
uspto-grants-2015_05
Patent number
US09034907B2

Reaction notes

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