Methyl 4-ethyl-2-isothiocyanato-5-methylthiophene-3-carboxylate → 5-ethyl-2,3-dihydro-6-methyl-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one

HRID 574703Notes

Reaction equation

HRID 574703 reaction equation
[CH2:1]([C:3]1[C:4]([C:12]([O:14]C)=O)=[C:5]([N:9]=[C:10]=[S:11])[S:6][C:7]=1[CH3:8])[CH3:2].[CH3:16][C:17]1[N:21]([CH2:22][CH2:23][CH2:24][NH2:25])[CH:20]=[N:19][CH:18]=1>>[CH2:1]([C:3]1[C:4]2[C:12](=[O:14])[N:25]([CH2:24][CH2:23][CH2:22][N:21]3[C:17]([CH3:16])=[CH:18][N:19]=[CH:20]3)[C:10](=[S:11])[NH:9][C:5]=2[S:6][C:7]=1[CH3:8])[CH3:2]

Participants

3

Reactant 2

HCID 4513532Methyl 4-ethyl-2-isothiocyanato-5-methylthiophene-3-carboxylateHCID 194294833-(5-methyl-1H-imidazol-1-yl)propan-1-amine

Product 1

HCID 251000435-ethyl-2,3-dihydro-6-methyl-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one

Procedure

The compound was synthesized starting from methyl 4-ethyl-2-isothiocyanato-5-methylthiophene-3-carboxylate (0.10 g, 0.41 mmol) and 3-(5-methyl-1H-imidazol-1-yl)propan-1-amine (5) (0.058 g, 0.41 mmol) as described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-098252f37d7f4eacaf0d162f15d9ce3d
Source dataset
uspto-grants-2015_05
Patent number
US09034907B2

Reaction notes

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