Methyl 2-isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate → 3-[3-(4-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one

HRID 574712Notes

Reaction equation

HRID 574712 reaction equation
[N:1]([C:4]1[S:8][C:7]2[CH2:9][CH2:10][CH2:11][CH2:12][C:6]=2[C:5]=1[C:13]([O:15]C)=O)=[C:2]=[S:3].[CH3:17][C:18]1[N:19]=[CH:20][N:21]([CH2:23][CH2:24][CH2:25][NH2:26])[CH:22]=1>>[CH3:17][C:18]1[N:19]=[CH:20][N:21]([CH2:23][CH2:24][CH2:25][N:26]2[C:13](=[O:15])[C:5]3[C:6]4[CH2:12][CH2:11][CH2:10][CH2:9][C:7]=4[S:8][C:4]=3[NH:1][C:2]2=[S:3])[CH:22]=1

Participants

3

Reactant 2

HCID 4512760Methyl 2-isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylateHCID 150349543-(4-Methyl-1H-imidazol-1-yl)propan-1-amine

Product 1

HCID 251002043-[3-(4-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one

Procedure

The compound was synthesized starting from methyl 4,5,6,7-tetrahydro-2-isothiocyanatobenzo[b]thiophene-3-carboxylate (0.109 g. 0.43 mmol) and 3-(4-methyl-1H-imidazol-1-yl)propan-1-amine (9) (0.060 g, 0.43 mmol) as described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-1ed5223680fc4e36b20c16989557bbef
Source dataset
uspto-grants-2015_05
Patent number
US09034907B2

Reaction notes

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