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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 574712Generated: October 27, 2026

Methyl 2-isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate → 3-[3-(4-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one

https://huagongshe.com/reaction/574712

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylateHCID 4512760—
Reactant3-(4-Methyl-1H-imidazol-1-yl)propan-1-amineHCID 15034954—
Product3-[3-(4-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-oneHCID 25100204—

Reaction Steps

The compound was synthesized starting from methyl 4,5,6,7-tetrahydro-2-isothiocyanatobenzo[b]thiophene-3-carboxylate (0.109 g. 0.43 mmol) and 3-(4-methyl-1H-imidazol-1-yl)propan-1-amine (9) (0.060 g, 0.43 mmol) as described above.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09034907B2
Source datasetuspto-grants-2015_05
ORD IDord-1ed5223680fc4e36b20c16989557bbef
Source noteuspto-grants-2015_05