Methyl 4-ethyl-2-isothiocyanato-5-methylthiophene-3-carboxylate → 2,3-dihydro-5,6-dimethyl-3-(3-(4-methyl-1H-imidazol-1-yl)propyl)-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one

HRID 574715Notes

Reaction equation

HRID 574715 reaction equation
[CH2:1]([C:3]1[C:4]([C:12]([O:14]C)=O)=[C:5]([N:9]=[C:10]=[S:11])[S:6][C:7]=1[CH3:8])C.[CH3:16][C:17]1[N:18]=[CH:19][N:20]([CH2:22][CH2:23][CH2:24][NH2:25])[CH:21]=1>>[CH3:1][C:3]1[C:4]2[C:12](=[O:14])[N:25]([CH2:24][CH2:23][CH2:22][N:20]3[CH:21]=[C:17]([CH3:16])[N:18]=[CH:19]3)[C:10](=[S:11])[NH:9][C:5]=2[S:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 4513532Methyl 4-ethyl-2-isothiocyanato-5-methylthiophene-3-carboxylateHCID 150349543-(4-Methyl-1H-imidazol-1-yl)propan-1-amine

Product 1

HCID 251003582,3-dihydro-5,6-dimethyl-3-(3-(4-methyl-1H-imidazol-1-yl)propyl)-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one

Procedure

The compound was synthesized starting from methyl 4-ethyl-2-isothiocyanato-5-methylthiophene-3-carboxylate (0.110 g. 0.46 mmol) and 3-(4-methyl-1H-imidazol-1-yl)propan-1-amine (9) (0.063 g, 0.46 mmol) as described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-7ff126a410d9488c96493da469c722b4
Source dataset
uspto-grants-2015_05
Patent number
US09034907B2

Reaction notes

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