反应详情

Tert-butyl piperidin-4-ylcarbamate (45.00 g, 225 mmol) and dihydro-2H-pyran-4(3H)-one (24.74 g, 247 mmol) were added to dichloromethane (1000 mL). Sodium triacetoxyborohydride (61.90 g, 292 mmol) was added, and the solution was stirred at room temperature for 16 hours. The solution was extracted with 1M sodium hydroxide and dried over anhydrous sodium sulfate. The solution was filtered and concentrated and purified by flash column chromatography on silica gel with 10% methanol (in dichloromethane) increasing to 20% methanol (in dichloromethane).

1. extractionThe solution was extracted with 1M sodium hydroxide
2. dry with materialdried over anhydrous sodium sulfate
3. filtrationThe solution was filtered
4. concentrationconcentrated
5. custompurified by flash column chromatography on silica gel with 10% methanol (in dichloromethane)
6. temperatureincreasing to 20% methanol (in dichloromethane)