Hydrochloric Acid → 3-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

HRID 574800Notes

Reaction equation

HRID 574800 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1)([O-:3])=[O:2].Cl>ClCCl.CCOCC>[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([NH2:11])(=[O:12])=[O:13])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67126453HCID 67126453, compound

Product 1

HCID 433458063-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 4-(2-nitro-4-sulfamoylphenylamino)piperidine-1-carboxylate was dissolved in dichloromethane (3 mL) and treated with 1N HCl in ether (4 mL). The reaction was stirred overnight then concentrated to give the title compound.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-5237c68b593e4813894a489d5b8c7c9b
Source dataset
uspto-grants-2015_05
Patent number
US09034875B2

Reaction notes

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