反应详情

A solution of EXAMPLE 258A (1.66 g) and sodium azide (0.581 g) in anhydrous N,N-dimethylformamide (10 mL) was stirred at 90° C. for 4 hours. The mixture was cooled and concentrated to dryness. The residue was taken up in 5% aqueous sodium carbonate solution and extracted with methylene chloride. The organic solution was dried (MgSO4), filtered and concentrated to give a solid.

1. temperatureThe mixture was cooled
2. concentrationconcentrated to dryness
3. extractionextracted with methylene chloride
4. dry with materialThe organic solution was dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customto give a solid