HCID 86647915, compound → HCID 67126817, compound

HRID 574949Notes

Reaction equation

HRID 574949 reaction equation
[CH2:1]([C:3]1([OH:21])[CH2:8][CH2:7][CH:6]([CH2:9][NH:10]C(=O)OCC2C=CC=CC=2)[CH2:5][CH2:4]1)[CH3:2]>O1CCCC1.[Pd]>[NH2:10][CH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH2:1][CH3:2])([OH:21])[CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 86647915HCID 86647915, compound

Product 1

HCID 67126817HCID 67126817, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of EXAMPLE 358A (500 mg) and 10% Pd/C (100 mg) in tetrahydrofuran (15 mL) was stirred under H2 for 3 hours. The insoluble material was removed by filtration, and the filtrate was concentrated to provide the title compound.

Workup

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-6844a8dccad14fa5aa66495107285e63
Source dataset
uspto-grants-2015_05
Patent number
US09034875B2

Reaction notes

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