反应详情

温度

100 °C

To a solution of EXAMPLE 363A (860 mg) in ethanol (30 mL) was added concentrated HCl (10 mL) and the mixture was stirred at 100° C. for 3 hours. The mixture was neutralized with solid Na2CO3 and extracted with dichloromethane (300 mL) and washed with aqueous NaHCO3, water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.

1. extractionextracted with dichloromethane (300 mL)
2. washwashed with aqueous NaHCO3, water, brine
3. dry with materialdried over Na2SO4
4. filtrationFiltration and evaporation of the solvent