反应详情

To a solution of EXAMPLE 363B (200 mg) in dichloromethane (6 mL) was added 3-(cyclopropylamino)propanenitrile (64 mg) followed by sodium triacetoxyborohydride (184 mg). The mixture was stirred overnight. The reaction mixture was diluted with dichloromethane (400 mL) and washed with 2N aqueous NaOH, water, and brine. After drying over Na2SO4, the mixture was filtered and evaporation of the solvent gave the title compound.

1. washwashed with 2N aqueous NaOH, water, and brine
2. dry with materialAfter drying over Na2SO4
3. filtrationthe mixture was filtered
4. customevaporation of the solvent