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HRID575189

反应详情

EQUATION

反应方程式

HRID 575189 的结构方程式

REACTANTS

反应物

2
结构：C#CC1(O)CCN(C)C1=O
HCID58221634

未命名化合物

结构：NC(=O)c1nc2c(s1)CCOc1cc(F)c(Br)cc1-2
HCID86693059

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCC(O)(C#Cc2cc3c(cc2F)OCCc2sc(C(N)=O)nc2-3)C1=O
HCID86693198

未命名化合物

收率 30%

PROCEDURE

实验过程

Similar to as described in General Procedure G, 9-bromo-8-fluoro-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide was reacted with 3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one (WO2009/158011A 1) to give the titled compound (34.8 mg, 30%).