HCID 58979602, compound → HCID 71715107, compound

HRID 575207Notes

Reaction equation

HRID 575207 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[F:20][C:21]([F:28])([F:27])[C:22]([CH3:26])([OH:25])[C:23]#[CH:24]>>[F:19][C:3]1[C:2]([C:24]#[C:23][C:22]([OH:25])([CH3:26])[C:21]([F:28])([F:27])[F:20])=[CH:18][C:6]2[C:7]3[N:8]([CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=3)[CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 58979602HCID 58979602, compoundHCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

Product 1

HCID 71715107HCID 71715107, compoundYield 40%

Procedure

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 1,1,1-trifluoro-2-methylbut-3-yn-2-ol (US2005/250741 A1) to give the titled compound as a white solid (80 mg, 40%).

Sources & evidence

ORD record
ord-375f56ace5084da3a2087e4182f2710d
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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