4-Pentynenitrile, 3-hydroxy-3-methyl- → HCID 86693242, compound

HRID 575233Notes

Reaction equation

HRID 575233 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[OH:20][C:21]([CH3:27])([C:25]#[CH:26])[CH2:22][C:23]#[N:24]>>[C:23]([CH2:22][C:21]([OH:20])([CH3:27])[C:25]#[C:26][C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1)#[N:24]

Participants

3

Reactant 2

HCID 122984934-Pentynenitrile, 3-hydroxy-3-methyl-HCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

Product 1

HCID 86693242HCID 86693242, compoundYield 30%

Procedure

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 3-hydroxy-3-methylpent-4-ynenitrile to give the titled compound as a brown solid (70 mg, 30%).

Sources & evidence

ORD record
ord-7319ad482c044730bf537b058c6cfd42
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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