HuagongsheHuagongshe Chemistry Print Report · For research reference only
TBDMS ether → 10-(4-Hydroxy-3,3-dimethylbut-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | TBDMS ether | HCID 590018 | — |
| Reactant | 10-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 68312883 | — |
| Reactant | Tert-butyl-(2,2-dimethyl-but-3-ynyloxy)-dimethyl-silane | HCID 86669580 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 10-(4-Hydroxy-3,3-dimethylbut-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 71715454 | 28% |
Reaction Steps
Similar to as described in General Procedure G, 10-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with tert-butyl[(2,2-dimethylbut-3-yn-1-yl)oxy]dimethylsilane to give the titled compound as a off-white solid (35 mg, 28%) after deprotection of the tert-butyldimethylsilyl ether (HF/MeCN).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-2cb8ae7c346648a6b6fef9a920bc995f |
| Source note | uspto-grants-2015_05 |