HRID575271

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID86693296

未命名化合物

结构：NC(=O)c1nc2n(c1COc1ccccc1Cl)CCOc1ccc(Br)cc1-2

HCID86693298

未命名化合物

PRODUCTS

生成物

结构：CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(COc4ccccc4Cl)n2CCO3)C1=O

HCID86693299

未命名化合物

收率 23%

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Similar to as described in General Procedure E with the exceptions of using Pd(PPh3)4 in DMSO, 10-bromo-3-((2-chlorophenoxy)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give the titled compound as a colorless solid (12 mg, 23%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-52bca7a5e40f498c95f68d90ec65cf0c
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09034866B2
来源说明: uspto-grants-2015_05

反应 SMILES

[C:1]([C@:3]1([OH:10])[CH2:7][CH2:6][N:5]([CH3:8])[C:4]1=[O:9])#[CH:2].Br[C:12]1[CH:13]=[CH:14][C:15]2[O:21][CH2:20][CH2:19][N:18]3[C:22]([CH2:28][O:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=4[Cl:36])=[C:23]([C:25]([NH2:27])=[O:26])[N:24]=[C:17]3[C:16]=2[CH:37]=1>CS(C)=O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Cl:36][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[O:29][CH2:28][C:22]1[N:18]2[CH2:19][CH2:20][O:21][C:15]3[CH:14]=[CH:13][C:12]([C:2]#[C:1][C@:3]4([OH:10])[CH2:7][CH2:6][N:5]([CH3:8])[C:4]4=[O:9])=[CH:37][C:16]=3[C:17]2=[N:24][C:23]=1[C:25]([NH2:27])=[O:26]