HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one → (R)-3-((2-chlorophenoxy)methyl)-10-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one | HCID 86693296 | — |
| Edukt | 10-Bromo-3-((2-chlorophenoxy)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693298 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | (R)-3-((2-chlorophenoxy)methyl)-10-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693299 | 23% |
Reaktionsschritte
Similar to as described in General Procedure E with the exceptions of using Pd(PPh3)4 in DMSO, 10-bromo-3-((2-chlorophenoxy)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give the titled compound as a colorless solid (12 mg, 23%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09034866B2 |
| Quelldatensatz | uspto-grants-2015_05 |
| ORD ID | ord-52bca7a5e40f498c95f68d90ec65cf0c |
| Quellennotiz | uspto-grants-2015_05 |