HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one → (R)-9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl) ethynyl)-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one | HCID 86693296 | — |
| Reactant | 9-bromo-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide | HCID 86693314 | — |
| Product | (R)-9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl) ethynyl)-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide | HCID 86693313 | 59% |
Reaction Steps
Similar to as described in General Procedure G, 9-bromo-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide was reacted with (3R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give the titled compound as an off-white solid (14.4 mg, 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-67e542e0ac1248c0918acb59599b4508 |
| Source note | uspto-grants-2015_05 |