HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol → (R)-9-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-methyl-4,5-dihydrobenzo[b]pyrazolo [1,5-d][1,4]oxazepine-2,3-dicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol | HCID 58221468 | — |
| Reactant | 9-bromo-N3-methyl-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2,3-dicarboxamide | HCID 86693336 | — |
| Product | (R)-9-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-methyl-4,5-dihydrobenzo[b]pyrazolo [1,5-d][1,4]oxazepine-2,3-dicarboxamide | HCID 86693337 | 26% |
Reaction Steps
Similar to as described in General Procedure G, 9-bromo-N3-methyl-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2,3-dicarboxamide was reacted with (R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol to give the titled compound as an off-white solid (37 mg, 26%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-e9d331dd018946c6a517cde291dbba07 |
| Source note | uspto-grants-2015_05 |