Dimethylformamide → HCID 86693371, compound

HRID 575337Notes

Reaction equation

HRID 575337 reaction equation
[NH2:1][CH2:2][C:3]1[N:7]2[CH:8]3[CH2:19][CH:10]([C:11]4[CH:16]=[C:15]([F:17])[C:14]([Br:18])=[CH:13][C:12]=4[C:6]2=[N:5][C:4]=1[C:20]([NH2:22])=[O:21])[CH2:9]3.CN(C)[CH:25]=[O:26]>>[Br:18][C:14]1[C:15]([F:17])=[CH:16][C:11]2[CH:10]3[CH2:9][CH:8]([CH2:19]3)[N:7]3[C:3]([CH2:2][NH:1][CH:25]=[O:26])=[C:4]([C:20]([NH2:22])=[O:21])[N:5]=[C:6]3[C:12]=2[CH:13]=1

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 86693372HCID 86693372, compound

Product 1

HCID 86693371HCID 86693371, compound

Procedure

3-(aminomethyl)-10-bromo-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was suspended in N,N-Dimethylformamide overnight to form crude 10-bromo-9-fluoro-3-(formamidomethyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide following extractive workup.

Sources & evidence

ORD record
ord-24927ee166aa4f699f166074eac0d396
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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