反应详情

To a solution of 4-bromobenzene-1-sulfonyl chloride (2.56 g, 10.0 mmol) and triethylamine (1.82 mL, 13 mmol) in DCM (50 mL) was added morpholine (960 mg, 11.0 mmol) dropwise and the mixture was stirred for 30 minutes at room temperature. Then the mixture was concentrated and extracted with EA, washed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine, dried and concentrated to give product as a white solid.

1. concentrationThen the mixture was concentrated
2. extractionextracted with EA
3. washwashed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine
4. customdried
5. concentrationconcentrated
6. customto give product as a white solid