Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 1,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one | HCID 71270309 | — |
| Reactant | 4-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidine | HCID 118021544 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | US10023592, Example 149 | HCID 118022283 | 35.6% |
Reaction Steps
A mixture of the title compound from step 3 (100 mg, 0.31 mmol), 1,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (93 mg, 0.37 mmol), Pd(dppf)Cl2 (23 mg, 0.31 mmol) and K3PO4 (199 mg, 0.94 mmol) in dioxane/water (3 mL/0.5 mL) was N2 purged and heated at 70° C. for 12 h. Concentration under vacuum and silica gel chromatography (PE:EA=3:10:1) followed by prep-HPLC gave the title compound (45 mg, 35.4%). 1H NMR (CDCl3, 400 MHz) δ 8.57 (s, 1H), 8.25 (s, 1H), 8.15 (s, 1H), 7.25-7.24 (m, 1H), 7.12-7.07 (m, 1H), 7.03 (t, J=8.0 Hz, 1H), 3.68 (s, 3H), 3.38 (s, 3H), 2.25 (s, 3H). LCMS: 407.9 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09034900B2 |
|---|
| Source dataset | uspto-grants-2015_05 |
|---|
| ORD ID | ord-14a17ed6d405420fa570b8b4d6511b78 |
|---|
| Source note | uspto-grants-2015_05 |
|---|
