Nitrogen → US10023592, Example 149

HRID 575632Notes

Reaction equation

HRID 575632 reaction equation
Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])=[CH:6][N:5]=[C:4]([S:17]([CH3:20])(=[O:19])=[O:18])[N:3]=1.[CH3:21][N:22]1[CH:27]=[C:26](B2OC(C)(C)C(C)(C)O2)[CH:25]=[C:24]([CH3:37])[C:23]1=[O:38].[O-]P([O-])([O-])=O.[K+].[K+].[K+].N#N>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[F:16][C:10]1[CH:11]=[C:12]([F:15])[CH:13]=[CH:14][C:9]=1[O:8][C:7]1[C:2]([C:26]2[CH:25]=[C:24]([CH3:37])[C:23](=[O:38])[N:22]([CH3:21])[CH:27]=2)=[N:3][C:4]([S:17]([CH3:20])(=[O:19])=[O:18])=[N:5][CH:6]=1

Participants

7

Reactant 4

HCID 947NitrogenHCID 62657Potassium Phosphate, TribasicHCID 712703091,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-oneHCID 1180215444-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidine

Product 1

HCID 118022283US10023592, Example 149Yield 35.6%

Reagents, catalysts & solvents 2

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)CatalystHCID 218864351,4-Dioxane--water (1/1)Solvent

Conditions

Temperature
70 °C

Procedure

A mixture of the title compound from step 3 (100 mg, 0.31 mmol), 1,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (93 mg, 0.37 mmol), Pd(dppf)Cl2 (23 mg, 0.31 mmol) and K3PO4 (199 mg, 0.94 mmol) in dioxane/water (3 mL/0.5 mL) was N2 purged and heated at 70° C. for 12 h. Concentration under vacuum and silica gel chromatography (PE:EA=3:10:1) followed by prep-HPLC gave the title compound (45 mg, 35.4%). 1H NMR (CDCl3, 400 MHz) δ 8.57 (s, 1H), 8.25 (s, 1H), 8.15 (s, 1H), 7.25-7.24 (m, 1H), 7.12-7.07 (m, 1H), 7.03 (t, J=8.0 Hz, 1H), 3.68 (s, 3H), 3.38 (s, 3H), 2.25 (s, 3H). LCMS: 407.9 (M+1)+

Workup

  1. custompurged
  2. concentrationConcentration under vacuum and silica gel chromatography (PE:EA=3:10:1)

Sources & evidence

ORD record
ord-14a17ed6d405420fa570b8b4d6511b78
Source dataset
uspto-grants-2015_05
Patent number
US09034900B2

Reaction notes

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