Iodoethane → US10023592, Example 162

HRID 575650Notes

Reaction equation

HRID 575650 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[C:7]([C:17]3[CH:22]=[C:21]([CH3:23])[C:20](=[O:24])[N:19]([CH3:25])[CH:18]=3)=[N:8][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[N:10][CH:11]=2)[CH2:3][CH2:2]1.[CH2:26](I)[CH3:27]>>[CH:1]1([CH2:4][O:5][C:6]2[C:7]([C:17]3[CH:22]=[C:21]([CH3:23])[C:20](=[O:24])[N:19]([CH3:25])[CH:18]=3)=[N:8][C:9]([N:12]([CH2:26][CH3:27])[S:13]([CH3:16])(=[O:15])=[O:14])=[N:10][CH:11]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 118022186US10023592, Example 153

Product 1

HCID 118022429US10023592, Example 162

Procedure

The title compound of Example 153 was treated with ethyl iodide in a manner similar to Example 161 to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.36-0.42 (m, 2H) 0.60-0.66 (m, 2H) 1.25 (t, J=6.82 Hz, 3H) 1.29-1.40 (m, 1H) 2.09 (s, 3H) 3.48 (s, 3H) 3.56 (s, 3H) 3.88-4.20 (m, 4H) 8.13 (s, 1H) 8.49 (s, 1H) 8.69 (s, 1H).). LCMS: 393 (M+H)+

Sources & evidence

ORD record
ord-77267262730d4ae68351a24242f776ee
Source dataset
uspto-grants-2015_05
Patent number
US09034900B2

Reaction notes

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