Ethanesulfonamide → US10023592, Example 168

HRID 575657Notes

Reaction equation

HRID 575657 reaction equation
[F:1][C:2]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:3]=1[O:4][C:5]1[C:6]([C:15]2[CH:16]=[C:17]([O:23][CH3:24])[C:18](=[O:22])[N:19]([CH3:21])[CH:20]=2)=[N:7][C:8](S(C)(=O)=O)=[N:9][CH:10]=1.[CH2:30]([S:32]([NH2:35])(=[O:34])=[O:33])[CH3:31]>>[F:1][C:2]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:3]=1[O:4][C:5]1[C:6]([C:15]2[CH:16]=[C:17]([O:23][CH3:24])[C:18](=[O:22])[N:19]([CH3:21])[CH:20]=2)=[N:7][C:8]([NH:35][S:32]([CH2:30][CH3:31])(=[O:34])=[O:33])=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 73702EthanesulfonamideHCID 118021426US10023592, Example 150

Product 1

HCID 118021498US10023592, Example 168

Procedure

The title compound of Example 150 was treated with EtSO2NH2 instead of MeSO2NH2 in a manner similar to Example 152, step 6 to give the title compound. 1H NMR (CDCl3, 400 MHz) δ 8.35 (d, J=2.0 Hz, 1H), 8.18 (s, 1H), 7.70 (d, J=2.0 Hz, 1H), 7.25-7.22 (m, 1H), 7.12-7.07 (m, 1H), 7.04-7.01 (m, 1H), 3.93 (s, 3H), 3.70 (s, 3H), 3.38 (s, 3H). LCMS: 423.9 (M+1)+

Sources & evidence

ORD record
ord-b1aeab643e3048ae979d4d73846ad2ed
Source dataset
uspto-grants-2015_05
Patent number
US09034900B2

Reaction notes

Loading…