反应详情

A solution of 1-fluoro-4-nitrobenzene (3.5 g, 24.81 mmol), methyl piperidine-4-carboxylate (4.26 g, 29.77 mmol) and K2CO3 in 40 mL of ACN, was stirred at reflux overnight. The mixture was added to 150 mL of water, extracted with EA, dried over Na2SO4. The volatiles were removed in vacuo, and the residue was purified by chromatography with PE/EA (10:1˜2:1) to give 3.84 g of methyl 1-(4-nitrophenyl)piperidine-4-carboxylate.

1. temperatureat reflux overnight
2. extractionextracted with EA
3. dry with materialdried over Na2SO4
4. customThe volatiles were removed in vacuo
5. customthe residue was purified by chromatography with PE/EA (10:1˜2:1)