HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 2-Ethyl-5-(methylsulfonyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Ethyl-4-methylsulfonyl-2-nitrobenzene | HCID 58266121 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Ethyl-5-(methylsulfonyl)aniline | HCID 28355896 | 94.6% |
Reaction Steps
The title compound of step 1 (0.6 g, 2.6 mmol) and palladium on carbon (0.18 g) in CH3OH (20 mL) was hydrogenated at 1 atm. for 6 h. Silica gel chromatography (PE:EA=6:1) gave the title compound (0.49 g, 94%) as a brown liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034900B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-5c34382e21f54caf975beac099012143 |
| Source note | uspto-grants-2015_05 |