2-(3-(Dibenzylamino)-2-hydroxypropyl)isoindoline-1,3-dione → 1-Amino-3-(dibenzylamino)propan-2-ol

Participants

Reaction Steps

A solution of 2-(3-(dibenzylamino)-2-hydroxypropyl)isoindoline-1,3-dione (4.5 g, 11.25 mmol) in conc. HCl (50 mL) was stirred at 120° C. overnight. After cooling to room temperature, the mixture was filtered. And the filtrate was extracted with CHCl3. The aqueous layer was added aq. 30% NaOH until pH was above 7, then the solution was extracted with CH2Cl2, dried over Na2SO4 and concentrated to give yellow solid (3.0 g).

Provenance & Evidence