反应详情

A solution of 2-(3-(dibenzylamino)-2-hydroxypropyl)isoindoline-1,3-dione (4.5 g, 11.25 mmol) in conc. HCl (50 mL) was stirred at 120° C. overnight. After cooling to room temperature, the mixture was filtered. And the filtrate was extracted with CHCl3. The aqueous layer was added aq. 30% NaOH until pH was above 7, then the solution was extracted with CH2Cl2, dried over Na2SO4 and concentrated to give yellow solid (3.0 g).

1. filtrationthe mixture was filtered
2. extractionAnd the filtrate was extracted with CHCl3
3. additionThe aqueous layer was added aq. 30% NaOH until pH was above 7
4. extractionthe solution was extracted with CH2Cl2
5. dry with materialdried over Na2SO4
6. concentrationconcentrated