1-Chloroethyl chloroformate → 3-(3-Chloro-4-fluorophenyl)-3-methoxypyrrolidine

Participants

Reaction Steps

Preparation according to Example 1: (−)-1-benzyl-3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidine (0.39 g, 1.22 mmol), 1,2-dichloroethane (20 ml), 1-chloroethyl chloroformate (0.69 g, 4.88 mmol). Purification by HPLC on waters OBD C18, 5 μm (MeOH/33 mM NH3, 20:80 to 50:50) gave the title compound 0.149 g (53%). [a]D=−3.4° (methanol). MS m/z (relative intensity, 70 eV) 229 (M+, 1), 199 (79), 187 (bp), 157 (42), 133 (41).

Provenance & Evidence