HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-(3-(dibenzylamino)-2-hydroxypropyl)acetamide → 6-((Dibenzylamino)methyl)morpholin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-(3-(dibenzylamino)-2-hydroxypropyl)acetamide | HCID 11725215 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 6-((Dibenzylamino)methyl)morpholin-3-one | HCID 9995550 | — |
Reaction Steps
A solution of 2-chloro-N-(3-(dibenzylamino)-2-hydroxypropyl)acetamide (1.0 g, 2.49 mmol), t-BuOK (0.39 g, 3.57 mmol) in t-BuOH (30 mL) was stirred at reflux overnight. After concentration, the residue was purified by column chromatography to give product as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3554ed25db0f4d5a8f454c2d718e4f90 |
| Source note | uspto-grants-2016_09 |