Potassium Hydroxide → HCID 86707280, compound

HRID 576078Notes

Reaction equation

HRID 576078 reaction equation
[OH-].[K+].[CH:3]1([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]([CH2:37][C:38]3[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=3)[S:18]([C:21]3[CH:22]=[C:23]4[C:28](=[CH:29][CH:30]=3)[CH2:27][N:26](C(=O)C(F)(F)F)[CH2:25][CH2:24]4)(=[O:20])=[O:19])=[C:13]([F:46])[CH:12]=2)[CH2:7][CH2:6][CH2:5][CH2:4]1>C(O)C.O>[CH:3]1([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]([CH2:37][C:38]3[CH:39]=[CH:40][C:41]([O:44][CH3:45])=[CH:42][CH:43]=3)[S:18]([C:21]3[CH:22]=[C:23]4[C:28](=[CH:29][CH:30]=3)[CH2:27][NH:26][CH2:25][CH2:24]4)(=[O:19])=[O:20])=[C:13]([F:46])[CH:12]=2)[CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 86707281HCID 86707281, compound

Product 1

HCID 86707280HCID 86707280, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

An aqueous solution (1 mL) of potassium hydroxide (29 mg, 0.51 mmol) was added to a solution of N-[4-(2-cyclopentylethoxy)-2-fluorophenyl]-N-(4-methoxybenzyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide obtained (163 mg, 0.26 mmol) in ethanol (4 mL), and the mixture was stirred at room temperature for 15 hr. The mixture was diluted with water and extracted with chloroform. The organic layer was concentrated under reduced pressure to afford the title compound as a colorless oil (145 mg).

Workup

  1. extractionextracted with chloroform
  2. concentrationThe organic layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-82b3a9445ce7402c854552026ac7de76
Source dataset
uspto-grants-2015_05
Patent number
US09035059B2

Reaction notes

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