Potassium Hydroxide → HCID 86707280, compound

Participants

Reaction Steps

An aqueous solution (1 mL) of potassium hydroxide (29 mg, 0.51 mmol) was added to a solution of N-[4-(2-cyclopentylethoxy)-2-fluorophenyl]-N-(4-methoxybenzyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide obtained (163 mg, 0.26 mmol) in ethanol (4 mL), and the mixture was stirred at room temperature for 15 hr. The mixture was diluted with water and extracted with chloroform. The organic layer was concentrated under reduced pressure to afford the title compound as a colorless oil (145 mg).

Provenance & Evidence