HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 3-(7-Chloropyrido[4,3-b]pyrazin-5-ylamino)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-(7-Chloropyrido[4,3-b]pyrazin-5-ylamino)propanoic acid | HCID 86717388 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(7-Chloropyrido[4,3-b]pyrazin-5-ylamino)propanamide | HCID 86717389 | — |
Reaction Steps
A solution of 3-(7-chloropyrido[4,3-b]pyrazin-5-ylamino)propanoic acid (2.22 mmol), HATU (2.66 mmol), DIPEA (6.65 mmol) and NH4Cl (4.43 mmol) in THF (10 mL) was stirred at room temperature overnight. The volatiles were removed under reduced pressure and the residue was treated with water. The precipitates were collected by filtration and dried to give the title compound. MS (m/z): 252 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-a8629fa55f2042d18372fb6dbcae1c48 |
| Source note | uspto-grants-2016_09 |