1,3-Propanediamine → N-(3-aminopropyl)-7-chloropyrido[4,3-b]pyrazin-5-amine

HRID 57629Notes

Reaction equation

HRID 57629 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][NH2:4].Cl[C:7]1[C:16]2[C:11](=[N:12][CH:13]=[CH:14][N:15]=2)[CH:10]=[C:9]([Cl:17])[N:8]=1>CO>[NH2:4][CH2:3][CH2:2][CH2:1][NH:5][C:7]1[C:16]2[C:11](=[N:12][CH:13]=[CH:14][N:15]=2)[CH:10]=[C:9]([Cl:17])[N:8]=1

Participants

4

Reactant 2

HCID 4281,3-PropanediamineHCID 717428275,7-Dichloropyrido(3,4-b)pyrazine

Product 1

HCID 86717390N-(3-aminopropyl)-7-chloropyrido[4,3-b]pyrazin-5-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of propane-1,3-diamine (890 mg, 12 mmol) and 5,7-dichloropyrido[4,3-b]pyrazine (600 mg, 3 mmol) in methanol (10 mL) was stirred at room temperature for 4 hours. The volatiles were evaporated, and the residue was purified by chromatography to afford the title compound. MS (m/z): 238 (M+H)+.

Workup

  1. customThe volatiles were evaporated
  2. customthe residue was purified by chromatography

Sources & evidence

ORD record
ord-4e864ae8fbc2468db10293ef3b4699ce
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Reaction notes

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