HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanediamine → N-(3-aminopropyl)-7-chloropyrido[4,3-b]pyrazin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanediamine | HCID 428 | — |
| Reactant | 5,7-Dichloropyrido(3,4-b)pyrazine | HCID 71742827 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(3-aminopropyl)-7-chloropyrido[4,3-b]pyrazin-5-amine | HCID 86717390 | — |
Reaction Steps
A solution of propane-1,3-diamine (890 mg, 12 mmol) and 5,7-dichloropyrido[4,3-b]pyrazine (600 mg, 3 mmol) in methanol (10 mL) was stirred at room temperature for 4 hours. The volatiles were evaporated, and the residue was purified by chromatography to afford the title compound. MS (m/z): 238 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-4e864ae8fbc2468db10293ef3b4699ce |
| Source note | uspto-grants-2016_09 |