反应详情

温度

55 °C

To a suspension of crude compound 28 (1.33 g, 1.54 mmol) and K2CO3 (0.322 g, 2.31 mmol) in acetone (20 mL) was added 3-bromopropanol (0.30 mL, 2.31 mmol) at r.t. The mixture was stirred at 55° C. for 15 hours. The reaction mixture was cooled to r.t and filtered off to remove inorganic salts. The filtrate was concentrated in vacuo. The residue was purified using normal phase column chromatography to provide the title product 29 (1.47 g, 100%).

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered off
3. customto remove inorganic salts
4. concentrationThe filtrate was concentrated in vacuo
5. customThe residue was purified