反应详情

温度

60 °C

Tert-butyl 4-bromophenylcarbamate (5.5 g, 20.21 mmol) was dissolved in THF, Lithium aluminum hydride (2.301 g, 60.63 mmol) was added and it was stirred at 60° C. overnight. Then it was quenched by EA, followed by H2O, concentrated and CH2Cl2 and 1M NaOH was added in, washed with CH2Cl2, extracted with CH2Cl2, dried over Na2SO4, concentrated, purified by flash chromatography (PE: EA=40:3) to give 2.1 g yellow oil.

1. customThen it was quenched by EA
2. concentrationconcentrated
3. additionCH2Cl2 and 1M NaOH was added in,
4. washwashed with CH2Cl2
5. extractionextracted with CH2Cl2
6. dry with materialdried over Na2SO4
7. concentrationconcentrated
8. custompurified by flash chromatography (PE: EA=40:3)