Hydrazine hydrate (1:1) → 3-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]propan-1-amine

HRID 576506Notes

Reaction equation

HRID 576506 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:28])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][N:17]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:10][CH2:9]2)[CH:7]=1.O.NN>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:28])=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH2:17])[CH2:12][CH2:13]2)[CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 585388742-(3-(4-(5-Chloro-2-methylphenyl)piperazin-1-yl)propyl)isoindoline-1,3-dione

Product 1

HCID 441227473-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]propan-1-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(3-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)propyl)isoindoline-1,3-dione (397 mg, 1.0 mmol) and hydrazine monohydrate (52 mg, 1.04 mmol) in ethanol (5 mL) was heated at 70° C. for 12 h. After the reaction cooled to room temperature, the solid was filtered off, and filtrate was evaporated to give the title compound, used without further purification.

Workup

  1. filtrationthe solid was filtered off
  2. customfiltrate was evaporated

Sources & evidence

ORD record
ord-65bc09e38ffe496ba0328fb081451f04
Source dataset
uspto-grants-2015_05
Patent number
US09040508B2

Reaction notes

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