Cyclopentanol → HCID 54596179, compound

Participants

Role	Name	HCID	Charge
Reactant	Cyclopentanol	HCID 7298	—
Reactant	Cesium carbonate	HCID 10796	—
Reactant	3-chloro-2-(4-(6-fluoropyridin-2-yl)benzyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione	HCID 70094773	—
Product	HCID 54596179	HCID 54596179	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

3-chloro-2-(4-(6-fluoropyridin-2-yl)benzyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (20 mg, 0.045 mmol), cesium carbonate (22 mg, 0.068 mmol) and cyclopentanol (0.3 mL) are placed in a Biotage microwave vial. The vial is sealed, and then heated in a Biotage microwave instrument at 150° C. for 4 h. The reaction mixture is purified with a semi-preparative HPLC to give 10.4 mg of pure product as pale yellow solids (Purity: 97.7%). MS (ESI) m/z 492.2 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09434730B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-b3bd6d9ae61e4f69851556bf2212894a
Source note	uspto-grants-2016_09