HRID57656
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
CONDITIONS
反应条件
- 温度
- 150 °C
PROCEDURE
实验过程
3-chloro-2-(4-(6-fluoropyridin-2-yl)benzyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (20 mg, 0.045 mmol), cesium carbonate (22 mg, 0.068 mmol) and cyclopentanol (0.3 mL) are placed in a Biotage microwave vial. The vial is sealed, and then heated in a Biotage microwave instrument at 150° C. for 4 h. The reaction mixture is purified with a semi-preparative HPLC to give 10.4 mg of pure product as pale yellow solids (Purity: 97.7%). MS (ESI) m/z 492.2 [M+H]+.
WORKUP
后处理
- customThe vial is sealed
- customThe reaction mixture is purified with a semi-preparative HPLC