反应详情

温度

69.5 °C

Commercially available 2-adamantanediol (yl), (500 g, 2.97 mol, Sigma-Aldrich), p-tosyl chloride (624 g, 3.27 mol, Sigma-Aldrich), and pyridine (1.5 L) were combined and stirred under an argon atmosphere. The reaction mixture was heated to a temperature in the range of 68-71° C. and remained at that temperature for 2.5 h. The reaction mixture was cooled to a temperature of about 25° C. and poured into saturated brine (6 L). The resulting mixture was extracted three times with MTBE (4 L for each extraction). The organic portions were combined, dried (MgSO4), filtered, and concentrated onto 1 kg silica gel (pre-treated with hexanes:TEA). The adsorbed material was chromatographed on 1.5 kg silica eluted sequentially with 1:10 EtOAc:hexanes (5 L) then 2:10 EtOAc:hexanes (5 L). All product fractions were combined and evaporated under reduced pressure to provide a residue. The residue was suspended in deionized water (2 L), stirred for 10 min, and filtered under reduced pressure to remove any excess reactants. The remaining solids were taken up in MTBE (2 L), dried (MgSO4), filtered, and evaporated under reduced pressure to provide 301 g of (1R,5S)-7-methylenebicyclo[3.3.1]nonan-3-one (y2) as a white crystalline solid (yield 67%).

1. temperatureThe reaction mixture was cooled to a temperature of about 25° C.
2. extractionThe resulting mixture was extracted three times with MTBE (4 L
3. extractionfor each extraction)
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated onto 1 kg silica gel (pre-treated with hexanes:TEA)
7. customThe adsorbed material was chromatographed on 1.5 kg silica
8. washeluted sequentially with 1:10 EtOAc
9. customevaporated under reduced pressure
10. customto provide a residue
11. stirringstirred for 10 min
12. filtrationfiltered under reduced pressure
13. customto remove any excess reactants
14. dry with materialdried (MgSO4)
15. filtrationfiltered
16. customevaporated under reduced pressure