Lawesson's reagent → HCID 90402344, compound

HRID 576722Notes

Reaction equation

COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:10])=CC=1.[Cl:23][C:24]1[C:41]([C:42]([F:45])([F:44])[F:43])=[CH:40][CH:39]=[CH:38][C:25]=1[CH2:26][N:27]1[CH:32]([CH:33]2[CH2:35][CH2:34]2)[CH2:31][NH:30][C:29](=O)[C:28]1=[O:37]>C1COCC1>[Cl:23][C:24]1[C:41]([C:42]([F:45])([F:44])[F:43])=[CH:40][CH:39]=[CH:38][C:25]=1[CH2:26][N:27]1[CH:32]([CH:33]2[CH2:35][CH2:34]2)[CH2:31][NH:30][C:29](=[S:10])[C:28]1=[O:37]

Participants

Conditions

Temperature: 55 °C

Procedure

To a heterogeneous mixture of Lawesson's reagent (289 mg, 0.69 mmol) in THF (13 mL) was added Intermediate 5 (480 mg, 1.4 mmol) in one portion. The mixture was heated at 55° C. for 20 minutes and then concentrated to remove solvent. Purification by chromatography (SiO2; hexanes—100% EtOAc) afforded the desired product as a yellow solid (434 mg, 86%). MS (ESI): mass calcd. for C15H14ClF3N2OS, 362.1; m/z found, 363.1 [M+H]+. 1H NMR (500 MHz, CDCl3) δ 9.40 (s, 1H), 7.63 (t, J=8.0 Hz, 2H), 7.36 (t, J=7.8 Hz, 1H), 5.23 (d, J=15.8 Hz, 1H), 4.74 (d, J=15.8 Hz, 1H), 3.73 (ddd, J=13.4, 4.0, 2.1 Hz, 1H), 3.57 (ddd, J=13.5, 5.2, 3.1 Hz, 1H), 2.81 (dd, J=8.5, 4.4 Hz, 1H), 1.24-1.11 (m, 1H), 0.79-0.67 (m, 1H), 0.63-0.55 (m, 1H), 0.51-0.45 (m, 1H), 0.21-0.08 (m, 1H).

Workup

concentrationconcentrated
customto remove solvent
customPurification by chromatography (SiO2; hexanes—100% EtOAc)

Sources & evidence

ORD record: ord-510c19ece3eb4ba785d6ea6fba4f867b
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09040534B2

Reaction notes

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