Formaldehyde → HCID 86723892, compound

HRID 576783Notes

Reaction equation

HRID 576783 reaction equation
[NH:1]1[CH2:4][CH:3]([N:5]2[C:10](=[O:11])[C:9]([C:12]3[N:16]([C:17]4[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=4)[N:15]=[CH:14][CH:13]=3)=[C:8]([CH3:25])[N:7]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=3)[C:6]2=[O:36])[CH2:2]1.[CH2:37]=O>>[CH3:25][C:8]1[N:7]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:34])([F:33])[F:35])[CH:27]=2)[C:6](=[O:36])[N:5]([CH:3]2[CH2:2][N:1]([CH3:37])[CH2:4]2)[C:10](=[O:11])[C:9]=1[C:12]1[N:16]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)[N:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 86723893HCID 86723893, compound

Product 1

HCID 86723892HCID 86723892, compound

Procedure

The intended compound was obtained by using 4-(5-(3-(azetidin-3-yl)-6-methyl-2,4-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidin-5-yl)-1H-pyrazol-1-yl)benzonitrile (prepared in Example 112) and formaldehyde according to the similar reaction and treatment method to those described in Example 69.

Workup

  1. customThe intended compound was obtained
  2. customto the similar reaction and treatment method to

Sources & evidence

ORD record
ord-6345badc850b4335a4f3d005d026f705
Source dataset
uspto-grants-2015_05
Patent number
US09040516B2

Reaction notes

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