反应详情

To a mixture of ethyl 3-(7-ethyl-4-oxo-4,5-dihydroimidazo-[1,5-a]-quinoxalin-1-yl)propanoate as synthesized in above Example 184, 50 mg and ethanol 3 mL, 1N sodium hydroxide solution 1.2 mL was added and heated under reflux for 2 hours. The reaction liquid was allowed to cool off, and to which 1N hydrochloric acid 1.2 mL was added. The precipitated crystals were recovered by filtration, washed with water and dried in flowing air to provide 37 mg of the title compound.

1. additionwas added
2. temperatureheated
3. temperatureunder reflux for 2 hours
4. customThe reaction liquid
5. temperatureto cool off
6. filtrationThe precipitated crystals were recovered by filtration
7. washwashed with water
8. customdried